“Another experimental COVID-19 vaccine is proving highly effective in trials, according to its manufacturer, offering the best hope yet that a large portion of the U.S. population will be getting immunized sometime in the coming year. The company, Moderna, said on Monday that its vaccine is 94.5% effective, based on a study of people who got either the actual vaccine or a placebo as part of a large-scale test that has been underway since the summer. Of the 95 people in the experiment who developed COVID-19 symptoms, 90 were in the placebo group, with several getting the most severe form of the disease. Of the five in the vaccine group who developed COVID-19 symptoms, none got its severe form. “The results in this trial are truly striking,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said during a telephone press conference convened by the National Institutes of Health. “I’d said I would be satisfied with a 70, 75% efficacy, that something like 95% was really aspirational … Well, our aspirations have been met, and that is really very good news.” Last week, Pfizer announced that its own vaccine was more than 90% effective, based on similar findings. Both manufacturers have indicated they intend to seek emergency approval from the U.S. Food and Drug Administration, and that if they get approval, they stand ready to start mass production. Moderna says it could produce enough to vaccinate 10 million people in the U.S. by the end of 2020, and Pfizer has said it could produce even more. Fauci and other experts were quick to issue the same cautionary notes they did last week ― that this is still based on interim data, and that approval will, and should, depend on more information about safety. The vaccine’s long-term effectiveness is also an open question. It’s not clear how long immunity would last, assuming the preliminary data holds up. 仍然, the Moderna news is especially encouraging, because its vaccine works in the same way that Pfizer’s does. Both use “messenger RNA,” which the human body uses as code to manufacture proteins. The vaccines have an artificially engineered version of mRNA that contains the instructions to create part of the COVID-19 virus ― in particular, the now widely recognizable spiky protein on the virus surface. When people get the vaccine, their cells start to produce the protein and the immune system reacts to it, developing a response that can then prevent the disease when people come into contact with the real virus. Or, at least, that’s always been the hope. Although mRNA vaccines have been in development for many years, nobody has produced and deployed one successfully, as both Pfizer and Moderna now seem to be on the verge of doing. The Moderna news increases confidence in COVID-19 vaccines for another reason. Although other manufacturers have tried approaches other than mRNA, they are similarly focusing on the spiky protein. If both the Pfizer and Moderna vaccines have indeed succeeded in generating an immune response, that’s more reason to think those other vaccines will too. “One of the things that we find is potentially good news for the future… is the consistency across different platforms,” Fauci said. “All of them use the spike protein as the target … Although you never want to get ahead of yourself and make predictions before the results of the trials are in, conceptually this looks good.” Nahid Bhadelia, an infectious disease specialist and associate professor at Boston University, told HuffPost that the announcement is “good news for sure” and bodes well for other vaccines, although she cautioned that the data still needs more review. Also, she said, “there are still questions regarding whether these vaccines protect from disease alone or also asymptomatic infection ― which could allow the vaccinated to continue transmitting ― and longevity.” The sort of rapid vaccine development associated with the coronavirus is unprecedented in human history. Experts said it was a product of decades of research, including into the development of the mRNA technique, as well as federal efforts through the Trump administration’s “Warp Speed” operation. Pfizer did not use Warp Speed money to underwrite its research, but Moderna did. Both have secured advance purchases and both expect to profit from sales, though the Trump administration has said the goal is to make sure all Americans get the vaccine for free. “The progress here, I think, does reflect this all-hands-on-deck approach, which has been taken since January by the entire scientific community ― that being NIH, academic centers and industry all working together in an unprecedented and seamless way,” NIH Director Francis Collins said. “Operation Warp Speed came along to make sure that all parts of the government were working together, moving swiftly.” The news from Pfizer and Moderna comes just as the U.S. is setting new daily records for COVID-19 cases and hospitalizations, with deaths rising as well. The situation looks more dire than it has at any point since the pandemic’s early phases, when the virus was brand-new to scientists and providers were still figuring out how to treat it. Medicine has now developed much better therapeutics, which has helped to reduce fatality rates. But rising caseloads are overwhelming providers in hot spots like the Dakotas and the Rio Grande Valley in Texas ― and even if the early returns from Pfizer and Moderna hold up, it will be many months before most of the population can get vaccinations, given production timetables. Distribution will be a huge challenge of its own, especially since the mRNA vaccines require cold storage, although Moderna’s does not appear to require the same sub-freezing temperatures as Pfizer’s. For those reasons, even experts enthusiastic about the vaccine trials say it’s critical that Americans, and their political leaders, not become complacent. “It’s more promising evidence that science will help us end this pandemic, and more reason for everyone to be especially vigilant now to stop this wave of infections, hospitalizations, and deaths,” Joshua Sharfstein, a former FDA deputy commissioner who is now a vice dean at the Johns Hopkins Bloomberg School of Public Health, 告诉HuffPost. “We should not let the accomplishment of an effective vaccine have us feel we can let our guard down,” Fauci said on the NIH phone call. “In fact, it should be an incentive to double down.”
Trump Administration Lowballs Unemployment Benefits In New COVID-19 Offer
144 观看次数0 评论0 喜欢
["The latest stimulus offer from the White House comes with one-time $600 payments for most Americans and a lump of coal for the unemployed. The new proposal offered by Treasury Secretary Steve Mnuchin swapped the $3...
Studies Suggest AstraZeneca COVID-19 Vaccine Safe And Effective
135 观看次数0 评论0 喜欢
["New results on a possible COVID-19 vaccine from Oxford University and AstraZeneca suggest it is safe and about 70% effective, but questions remain about how well it may help protect those over 55 — a key concern for...
COVID-19 Deaths, Georgia Elections And Trump Pardons: Views From HuffPost Readers
132 观看次数0 评论0 喜欢
["HuffPost Illustration In a recent poll, one of HuffPost members’ top-requested features was a roundup of reader comments. Every week, HuffPost editors read your comments on our top stories and highlight those that c...
Once Again, Georgia Certifies Election Results Confirming Biden’s Win
112 观看次数0 评论0 喜欢
["ATLANTA (美联社) — Georgia’s top elections official on Monday recertified the state’s election results after a recount requested by President Donald Trump confirmed once again that Democrat Joe Biden won the state, 和 ...
Fauci Warns Christmas May Bring More COVID-19 Cases Than Thanksgiving
62 观看次数0 评论0 喜欢
["Dr. Anthony Fauci has warned that Christmas and Hanukkah may bring more COVID-19 cases than the surge anticipated from Thanksgiving due to the number of days people are likely to spend celebrating with family and fr...
Singer Jeremih Leaves Hospital After COVID-19 Battle, Says He’s ‘Forever Grateful’
364 观看次数0 评论0 喜欢
["Singer Jeremih has been released from the Northwestern Memorial Hospital in Chicago after battling COVID-19 during his stay, his family said. The 33-year-old R&B artist, whose real name is Jeremy Felton, thanked th...
Tuesday Is ‘V-Day’ In Britain; First Citizens Will Get COVID-19 Vaccine
153 观看次数0 评论0 喜欢
["LONDON (美联社) — It’s been dubbed “V-Day” in Britain ― recalling the D-Day landings in France that marked the start of the final push in World War II to defeat Nazi Germany. A week after the U.K. became the first Weste...
Selma Blair And Sarah Michelle Gellar Redo ‘Cruel Intentions’ Kiss For COVID-19 Era
73 观看次数0 评论0 喜欢
["More than 20 years after they co-starred in “Cruel Intentions,” Selma Blair and Sarah Michelle Gellar continue to find ways to reference their legendary screen kiss. The actors made a virtual appearance at Sunday’s...